The only element which was missing from the Ospreys' dominant display was a bonus point.
The Welsh derby was expected to be a close encounter but the Blues were a shadow of the side that scored five second-half tries in a 42-13 hammering of Newport Gwent Dragons.
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Hide AdAnd the Ospreys, boosted by having Lions pair Adam Jones and Lee Byrne in the starting line-up, were too incisive in attack with first-half tries for Walker and a second-half effort from Ryan Jones.
Man of the match Dan Biggar provided 11 points with the boot.