The Hull City attacker damaged ankle ligaments during his side’s 2-0 Premier League defeat by Stoke City on Saturday and has been ruled out for four weeks..
Scotland’s match at Wembley on 11 November had always been highlighted as the toughest test of the campaign, but has now taken on even greater importance following the home draw with Lithuania and defeat in Slovakia earlier this month.
A statement released by Hull on Twitter said: “Scans have confirmed that Snodgrass sustained ankle ligament damage during Saturday’s Premier League game against Stoke City.
“As a result, the Scottish international is expected to be out of action for up to four weeks.”
Snodgrass has become an influential member of Gordon Strachan’s side, scoring a hat-trick in the opening qualifier, a 5-1 victory in Malta, and is Scotland’s top scorer of the campaign so far.
The national coach recently paid tribute to the player for the way he fought back from a serious knee injury which kept him out for over a year.
News of Snodrass’s injury comes as a further blow following the loss of Andrew Robertson, his team-mate for both club and country, who has been ruled out for two months with a calf injury.