Boyd faces up to two months on the sidelines following a training-ground injury after hitting three goals this season.
But Clark has options up front ahead of Friday night’s visit of Ladbrokes Premiership leaders Celtic.
Souleymane Coulibaly has nine goals this season despite mostly playing out wide, former Nottingham Forest striker Nathan Tyson has seven games under his belt following his arrival at Rugby Park, and 20-year-old Flo Bojaj has impressed his manager in training in recent weeks.
Clark said: “We have lost Kris Boyd with a thigh strain for the next four to eight weeks so that’s a big blow both on and off the pitch.He has been a big catalyst for what I have been trying to achieve, to try and get the players to do and the tweaks I have made to certain things, he has been a big advocate of that. He has done terrifically well for us on the pitch as well.
“Potentially (Coulibaly) could play in his proper position, Nathan Tyson as well gives us that strength and pace through the top, and Flo Bojaj has come on in the last few weeks and been the player we thought we were bringing through the door. He is at the forefront of our mind too. It’s an opportunity for those three lads now to stake a claim while Kris is out and get the position.”
Steven Smith and Scott Boyd have shaken off knocks while Charlee Adams and Callum McFadzean have returned to training following injury, although the pair might not make Friday’s game. Defender Miles Addison is struggling to overcome a foot injury in time to face the champions.