Brendan Rodgers’ side lead 5-2 from the first leg and anything better than a three-goal defeat will see them through.
Here is all you need to know about the second leg encounter at the Turner Stadium.
Kick off: 7.45pm (GMT)
Where to watch: BT Sport (coverage starts at 7pm)
Probable Beer-Sheva team (5-4-1): Goresh; Bitton, Hoban, Taha, Tzedek, Davidzada; Melikson, Radi, Sahar, Mwakaeme; Maranhao. Subs from: Haimov, Ohayon, Turgeman, Shabtai, Broun, Bitton, Ogu, Buzaglo, Palhano Soares, Rubin, Vitor, Rahamin.
Probable Celtic team (4-2-3-1): Gordon; Lustig, Toure, O’Connell, Tierney; Brown, Bitton; Forrest, Rogic, Sinclair; Griffiths. Subs from: De Vries, Fasan, Dembele, Izaguirre, McGregor, Armstrong, Roberts, Janko, O’Connell, Ajer, Christie, Ciftci, Johansen.
Unavailable: Simunovic, Boyata, Mackay-Steven
Referee: Bas Nijhuis (The Netherlands)
Hapoel Beer-Sheva key player: Nigerian attacker Anthony Nwakaeme played his part in both of Beer-Sheva’s goals in the first leg, though he only began to look threatening after switching out to the left wing at the beginning of the second half. Beer-Sheva surprised everyone by going 3-5-2 in the first leg and the gamble didn’t work out. It remains to be seen whether they revert to their preferred 5-4-1 when they need to win by such a healthy margin.
Celtic key player: There will be a lot of room on the counter attack for the visitors to exploit. Leigh Griffiths will be expected to drop deep at times to link play as the head of the attack, so look for Scott Sinclair to make those advancing runs beyond the striker, drifting in from the left wing. It helped create the opening goal last week and if it repeats the feat just once in Israeli then Celtic will be all but assured of advancing to the group stages.
Last meeting: Celtic 5 - 2 Hapoel Beer-Sheva
Odds: Beer-Sheva 13/10 Draw 13/5 Celtic 19/10
What Beer-Sheva are saying: “We are up against a better team, we know the last result but we still believe a little. We come with confidence and we will give everything tomorrow; it is my players that give me that confidence.” (Hapoel Beer-Sheva boss Barak Bakhar)
What Celtic are saying: “For myself and the players it is about operating at the highest level you can. We fought so hard all pre-season, we now have that one final step to take and I believe we are ready to take it.” (Brendan Rodgers)