The Irishman started last weekend's game against Hamilton but was struggling throughout with a toe problem that he had suffered in the previous game against the Parkhead side.
He has not trained all week and has joined skipper Chris Hogg, Paul Hanlon, David Wotherspoon, Merouane Zemmama, Alan Gow, Sean Welsh, Lee Currie and Brown in the treatment room.
With Liam Miller already suspended for the trip to Glasgow, Hughes said: "We'll have to give Patrick a few more days, it's unlike him not to train.
"He took a kick on his toe against Celtic and I thought that he did well to start against Hamilton. We've already got a few boys struggling and Liam Miller is suspended so we're keeping our fingers crossed that Patrick manages to train tomorrow. He's working with the physio today and we'll take it from there."
Zemmama had surgery in London last night in a bid to cure the knee problem which has ruled him out for the remainder of the season and Hughes added: "Zouma went through his operation and we're all keeping our fingers crossed that the surgery went okay.
"He's certainly got the right attitude and he's a good player to have in the squad. We're all looking forward to having him back in the side again."
Meanwhile, Hughes was at Parkhead last night to see Motherwell lose 2-1 to Celtic in the SPL, a result which leaves the Steelmen two points behind Hibs having played the same number of games. Hughes insisted that he's focusing 100 per cent on what his own team do and not on looking for favours from other sides, however he added: "We're concentrating on ourselves and making sure we get the right results but obviously if Celtic and Rangers win their games and we can pick up points against the Old Firm then that sends us in the right direction."