Queensferry Boxing Club have two sets of siblings, Mark and Chris McHale, and Owen and Sean Spence, set to compete while Craigmillar brothers James and Peter Casey will also go for glory.
The Queensferry coach, Mark Geraghty, said: "I have high hopes that light-flyweight Mark McHale and his big brother, light-welterweight Chris, will win titles at Danderhall – especially Chris, who is seeking to make it three Eastern titles in a row.
"We are actually entering two sets of brothers in these championships with welterweight Owen Spence and older brother Sean, a lightweight, looking to win titles too."
Craigmillar will be have no fewer than seven entries and the Capital outfit's leading official, Stewart Anderson, claimed: "We reckon Joe Murray (light-flyweight] and Daniel Wickstead (flyweight] will give any opponent a stiff challenge although at light-flyweight Midlothian's Scottish champion Barry Hogg will definitely be the guy to beat.
"We too, have entered brothers –James and Peter Casey – so it's possible that we could see three sets of brothers crowned as championships at Danderhall."
Edinburgh's oldest boxing club, Leith Victoria, have two fighters on duty in featherweight Sean White and light-welterweight Josh Rogers.
Gilmerton's British champion Conor McMillan won't box at the event as previously intimated and he explained: "I've decided to keep my powder dry until the Scottish Championships in March."
Lochend hold high hopes for Kevin Skey, Liam Tervit and Brad Forbes while Midlothian's Barry Hogg and Scott Devine are in with a chance.
Entry to Danderhall Community Centre on Saturday will cost 7 for adults and 5 for concessions. Boxing starts at 1.00pm.