A day after turning 37, Bohn clinched the second PGA Tour title of his career having completed his third round in the morning and then posted a final-round, five-under-par 67.
His 18-under total was two better than fellow American Jeff Overton for his first victory since the 2005 BC Open.
Rookie Troy Merritt finished third on 14-under par and two-time US Open champion Lee Janzen was fourth a further shot back.
Having secured his PGA Tour card for at least another two years and booked a place at next year's Masters with the win, Bohn was understandably overjoyed with the birthday gift to himself.
"Am I 37? No," Bohn said with a smile. "I feel like 22 right now.
"More so than anything, this changed my life in the fact that every guy out here when they start the year with full status, your number one goal is to win on the PGA Tour.
"It locks up a job. You know you've got a job for two years. The security of that is unbelievable
. To know that I'm now a multiple winner on the PGA Tour has changed my life."
The player had led since an opening 65 and stretched his lead after the rain and lightning-delayed second round from two to four before it was chipped away heading into the final round.
Bohn, who had completed his third round on Sunday morning at 13 under, led by two shots over Germany's Alex Cejka after 54 holes with Overton and Janzen at ten under.
Merritt, 24, had got to 15 under and into a one-shot lead over Bohn with five to play but then bogeyed the 14th as Bohn birdied the 11th to retake a lead he would not surrender again.
He sank birdies at the 15th and 16th holes before pitching from 140 yards out to four inches from the 18th hole for a guaranteed birdie and victory.
Overton closed with a birdie to get to 16 under with a six-under 66 and second place with Merritt taking a 67 for third place and Janzen a 69 for fourth.
England's Greg Owen and Sweden's Daniel Chopra were the leading Europeans as part of a tie for 16th place.
Cejka fell out of contention and had to settle for a share of 21st with a two-birdie, six-bogey 76.
England's Justin Rose had a three-birdie, one-bogey 70 to finish on four under and Brian Davis closed with a 76 on two under for the week, seven days on from his runner-up finish at the Verizon Heritage, when he called a penalty on himself during a sudden-death play-off with Jim Furyk.
Sergio Garcia's problems returned with a closing 76 that left him two over.