Emergency services attended a premises on Well Street in Paisley at around 4.30am on Saturday.
Members of the public were asked by police to avoid the area, although no injuries have been reported.
Police Scotland said: “Emergency services are dealing with a report of a gas explosion at a premises in Well Street, Paisley.
“Well Street is completely closed, as well as a number of surrounding streets. The train line running through Paisley Gilmour Street is also affected. Please avoid the area.”
At around 8.30am, police provided an update that a cordon around Well Street had been reduced while emergency services continued to deal with the incident.
ScotRail has told passengers that services are expected to return to normal after earlier services between Glasgow Central, Largs and Ardrossan Harbour were suspended.
A number of surrounding roads were also cordoned off by police.
In a statement published at around 8.50am, Renfewshire Council said: “Following the incident at Well Street, repairs are on-going and Well Street remains closed, but the safety cordon is being lifted on surrounding streets.
“This means our waste collection teams are now able to start their Saturday collections.”