The genetic basis of anorexia nervosa overlaps with metabolic, lipid and body measurement traits, according to researchers.
They say this is independent of genetic factors that influence body mass index.
A metabolic disorder can happen when abnormal chemical reactions in the body alter the normal metabolic process.
Dr Gerome Breen, from the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at King’s College London, said: “Metabolic abnormalities seen in patients with anorexia nervosa are most often attributed to starvation.
“But our study shows metabolic differences may also contribute to the development of the disorder. Furthermore, our analyses indicate that the metabolic factors may play nearly or just as strong a role as purely psychiatric effects.”
Another finding was the genetic basis of anorexia overlaps with other psychiatric disorders such as obsessive-compulsive disorder, depression, anxiety and schizophrenia.
Genetic factors associated with anorexia also influence physical activity, which could explain the tendency for people with anorexia to be highly active, the research indicates.
Eight genetic variants linked to anorexia were identified in the large-scale, genome-wide association study.
Anorexia is a serious and potentially life-threatening illness. Symptoms include a dangerously low body weight, an intense fear of gaining weight and a distorted body image.
It affects between 1 per cent to 2 per cent of women and up to 0.4 per cent of men. It has the highest mortality rate of any psychiatric illness.
Researchers combined data collected by the Anorexia Nervosa Genetics Initiative and the Eating Disorders Working Group of the Psychiatric Genomics Consortium.
The dataset included 16,992 cases of anorexia and 55,525 controls from 17 countries across North America, Europe and Australasia. Professor Janet Treasure, also from the Institute of Psychiatry, Psychology & Neuroscience at King’s College London, said: “Over time there has been uncertainty about the framing of anorexia nervosa because of the mixture of physical and psychiatric features. Our results confirm this duality and suggest that integrating metabolic information may help clinicians to develop better ways to treat eating disorders.”
The study concludes anorexia may need to be thought of as a hybrid “metabo-psychiatric disorder” and that it will be important to consider both metabolic and psychological risks factors when exploring new avenues for treatment. The study is published in Nature Genetics.