The cameras, which record speeds over set distances, will initially be used on the M74, followed by the M73, M8 and A8 until spring 2017.
The normal 70mph limit will be cut to 50mph, or lower “where required to maintain safety”. The 100,000 vehicles a day which use the roads also face contraflows and narrowed lanes.
The first section to be covered will be between junction three at Carmyle and junction six at Hamilton on the M74.
That will be followed by the M73 between junction one at Maryville and junction two at Baillieston.
Cameras will then be used on the M8 between junction ten at Easterhouse and junction eight at Baillieston.
They will also cover the A8 between Baillieston and Newhouse, where a new section of motorway is being built.
Graeme Reid, of the Scottish Government’s Transport Scotland agency, said: “Not only do the cameras create a safer environment, they can also help improve the flow of traffic.”