The incident, involving two vehicles, happened on the busy route heading northbound between junction 5 Auchenkilns and junction 6 Old Inns, North Lanarkshire, just before 7am.
Commuters have been warned to expect tailbacks as a result of the incident.
A Police Scotland spokesman said: “We are currently dealing with a crash on the M80 involving two cars.
“Delays are being caused. Police are still at the scene.”