The bridge, which connects the Old and New Town, will be shut to traffic from 8pm tonight until 6am on Monday.
Lothian, the city’s main bus operator will re-route its services 3,5, 7, 8, 14, 29, 30, 31, 33, 37 and 49.
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Services 3 29 30 31 33 37 will be diverted from Nicolson Street via Chambers Street, George IV Bridge, The Mound, Hanover Street, George Street and South St David Street in both directions.
Northbound services 5 7 8 14 49 will be diverted from Nicolson Street via Chambers Street, George IV Bridge, The Mound, Hanover Street, George Street, South St Davids Street and Princes Street.
Southbound services will be re-routed from Picardy Place via Princes Street, South St Davids Street, George Street, Hanover Street, The Mound, George IV Bridge and Chambers Street.
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Lothian's 7 service will be among those affected.
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