Police were called to a report of a crash in Balkerach Street, Doune, near Stirling, at around 10:25am on Thursday.
The 26-year-old man in the cherry-picker bucket suffered serious injuries and was pronounced dead at the scene.
The road was closed while emergency services dealt with the incident.
A Police Scotland spokesman said: “Inquiries into the full circumstances of the collision are ongoing and the Health and Safety Executive have been notified.”
The crash came just 12 hours after a man was taken to hospital following a collision between a cherry-picker and a bus in Glasgow.
The incident in George Square happened at around 10:20pm on Wednesday.
It is understood the cherry-picker toppled over through a bus stop and came to rest on the bus.
A man who was in the aerial platform suffered minor injuries and was taken to Glasgow Royal Infirmary for treatment.