Several large initiatives will be helped by the Scottish Government cash injection, including a maximum 40,000 grant for the Royal Botanic Garden.
It will run its From Another Kingdom exhibition aimed at 80,000 people across the country with the cash.
Support will also be given to the Scottish National Blood Transfusion Service for a stem cells initiative; the Edinburgh International Science Festival; Archeology Scotland for a Lothians project; and Edinburgh University for a science roadshow for schools.
Others to receive money from the 400,000 pot include the National Museum in Edinburgh and Time-Tastical Productions for work it has planned during the upcoming festival.
Professor Anne Glover, Chief Scientific Adviser for Scotland said: "Science and innovation have long been part of our culture in Scotland.
"These projects continue that tradition by raising awareness of science across the country.
"They will give thousands of people the chance to explore science by meeting researchers and discussing their work, much of which is world-leading. Young people in particular will enjoy inspiring visits to their schools from a number of initiatives."