The Albuquerque Journal reported that the captain declared a medical emergency on flight 1353 a couple of minutes before landing at Albuquerque International Sunport on Wednesday evening.
A spokesman for the airline told the newspaper that the captain landed the flight from Dallas-Fort Worth without incident.
The plane taxied normally to a gate and was met by paramedics.
American Airlines first officer William “Mike” Grubbs was pronounced dead.
There was no immediate word on a cause of death.
In 2015, an American Airlines pilot died on a flight from Phoenix to Boston.