New MS treatment ‘can freeze progression of disease’

Imperial College London. Picture: Wikicommons
Imperial College London. Picture: Wikicommons
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A multiple sclerosis treatment which “resets” the immune system has been found to “freeze” progression of the disease in nearly half of patients, according to scientists.

A study led by Imperial College London found that 46 per cent of patients who underwent the treatment did not suffer a worsening of their condition for five years.

The treatment could give hope to the estimated 100,000 people in the UK who are affected by multiple sclerosis (MS), for which there is currently no cure.

MS - which is caused by the immune system malfunctioning and mistakenly attacking nerve cells in the brain and spinal cord - can lead to patients suffering problems with movement, vision, balance and speech.

The treatment, autologous hematopoietic stem cell transplantation (AHSCT), was given to patients with advanced forms of the disease who had failed to respond to other medications.

Dr Paolo Muraro, the study’s lead author, said: “We previously knew this treatment reboots or resets the immune system - and that it carried risks - but we didn’t know how long the benefits lasted.

“In this study, which is the largest long-term follow-up study of this procedure, we’ve shown we can ‘freeze’ a patient’s disease - and stop it from becoming worse, for up to five years.”

However, researchers noted that the nature of the treatment, which involves aggressive chemotherapy, meant it carried significant risks.

The chemotherapy deactivates the immune system for a short period of time, which can lead to greater risk of infection - of the 281 patients who received AHSCT, eight died in the 100 days after treatment.

Older patients and those with the most severe forms of MS had a higher risk of death.

The treatment works by destroying the immune cells responsible for attacking the nervous system.

Patients were given a drug which encourages stem cells to move from the bone marrow into the bloodstream, where they were removed from the body.

High-dose chemotherapy was then administered to kill all immune cells, before the patient’s own stem cells were put back into the body to “reset” the immune system.

The study, published in the journal JAMA Neurology, found that patients with differing forms of MS fared differently after receiving treatment.

Nearly three in four (73%) patients with relapsing MS - where the disease flares up before symptoms improve - found their symptoms did not worsen for five years after having AHSCT, compared with one in three patients with progressive MS, the more severe variant of the disease.

Dr Sorrel Bickley, head of biomedical research at the MS Society, said the charity helped fund the study to “find treatments for everyone”.

She said: “If anyone with MS is considering AHSCT, they should speak to their neurologist as a referral is needed to access this treatment via a trial or on the NHS.”