The man, who was in his thirties, was pronounced dead shortly after arriving in hospital in Edinburgh.
The collision happened at about 11.40pm on the bypass half a mile east of the Sheriffhall roundabout in Edinburgh.
The man was taken to Edinburgh Royal Infirmary for treatment but was pronounced dead a short time later.
The driver of the lorry was not injured.
Lothian and Borders Police have appealed for witnesses.