The website, of which the Evening News' online coverage is part, has attracted a record number of visitors since the start of the year, with around 180,000 unique users a month.
With a spend of 2 million over the next four months, the advertising campaign has been devised by creative agency 60 Watt with media planning by Feather Brooksbank.
It uses a number of channels including radio advertising, outdoor posters, online, search, print and e-mail.
The theme of the campaign has been inspired by the website postsecrets.com and taps into the "secret" world of emotions experienced by jobseekers.
Peter Mill, creative director of 60 Watt says: "This is a wonderful opportunity to get inside the heads of jobseekers and explore the very real hopes, fears, highs and lows experienced by everyone who aspires to pursuing a better career."
Initially targeting Edinburgh and the Lothians, the campaign will be rolled out across Scotland later in the year.