Boris Johnson and Brexit Party leader Nigel Farage have yet to respond to a request to attend the hour-long Emergency On Planet Earth debate on Channel 4 News, which will focus solely on climate change.
The broadcaster said the debate will take place even if they are unable to take up the invitation.
Channel 4 has invited seven party leaders to the discussion, but so far only Labour leader Jeremy Corbyn, Scottish First Minister and SNP leader Nicola Sturgeon, Liberal Democrat leader
Jo Swinson and Green co-leader Sian Berry have accepted the invitation.
Ben de Pear, editor of Channel 4 News, said: "There is no more urgent issue facing the planet and we are delighted to open the whole of our programme for all the party leaders to show what plans they have to confront it."
Presenter Krishnan Guru-Murthy added: "It is a huge privilege to be hosting the people who want to run the country debating the most important issue in the world.
"How much do we need to change the way we live? Is it the end of fast fashion, fast cars, foreign holidays and red meat? Do any of them have a credible plan to cut our net emissions to zero?"
The debate will take place on Thursday at 7pm and will begin with a short opening statement from each leader.