The Prime Minister will take charge of a remote meeting of his top team following battling the disease, and a day after he became a father again.
The meeting comes as Scotland's First Minister Nicola Sturgeon said easing lockdown would not be a "flick of the switch moment".
The Scientific Advisory Group for Emergencies (SAGE) is also gathering on Thursday before Mr Johnson fronts the daily Downing Street press conference once again.
SAGE is looking at a selection of options for easing restrictions while still keeping the reproduction rate of the coronavirus - the number of new cases linked to a single individual - below one in order to stop it spreading exponentially.
Business Secretary Alok Sharma was reported to be set to put forward plans for an eventual "work place by work place" easing of lockdown in the coming days.
A Business Department spokesman said: "The Government has already set out five clear tests to consider before making any adjustment to its approach. It is only right the we work together with industry and unions to ensure workplaces are safe for both those in work now and for those going back to work as government measures develop."
It will not be known until Friday whether the Government has met its 100,000 a day test pledge.
Ms Sturgeon said she was "far from convinced" measures could be eased on the next review date of May 7.
The Scottish First Minister told ITV's Peston: "People talk about lifting the lockdown, that is not going to be a flick of the switch moment - we're going to have to be very careful, very slow, very gradual.
"I'm far from convinced at this stage that when we get to the next review point on the 7th of May we'll be in a position to lift any of these measures right now, because the margins of manoeuvre that we're operating in right now are very, very, very tight and narrow.
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