Numbers crunched by the Press Association show that approximately 21,413 staff have been made redundant or seen their role put under threat, with the bulk of them working for well known high street chains.
Since January Toys R Us and Maplin have filed for administration, while fashion retailers such as New Look and Select have embarked on radical store closure programmes.
Only last week, Bargain Booze owner Conviviality said it plans to call in administrators within the next 10 days, putting 2,600 jobs at risk.
Retailers have been hammered by Brexit-fuelled inflation, soaring business rates and falling consumer confidence, but experts also point to structural changes in the sector.
Duncan Brewer, partner at consultancy Oliver Wyman, said: "What we're seeing play out is a mixture of different things.
"Cost is one of the biggest pressures out there. The devaluation of sterling, increased labour costs and business rates will be having an effect.
"The high cost operating model businesses that are not offering customers what they want are being squeezed by better quality, or lower-cost rivals that are.
"We're also seeing a move towards improvements in productivity, with some businesses positioning themselves for the future, which will leave others less able to compete."
Supermarket giants have also made swingeing cuts to shop floor staff, with Morrisons, Sainsbury's and Tesco axing 5,200 roles between them.
Mr Brewer added that the sector's future prospects are dependent on consumer confidence, which has tanked since the Brexit vote.
Elsewhere, the collapse of outsourcer Carillion has so far resulted in over 1,700 job losses, with more pain expected.
British Gas owner Centrica has recently announced it will axe 4,000 roles over the next three years under a ramped-up efficiency programme.
Compounding the misery was the closure of Norwich's iconic Colman's mustard factory, which saw 113 workers culled and was followed by drinks giant Coca-Cola shutting sites in Milton Keynes and Northampton.
Unions have placed the blame for the dire figures firmly at the feet of the Government, blaming Theresa May's Conservative party for economic mismanagement.
Tim Roache, general secretary of the GMB union, said: "A strong economy doesn't see job losses like this. It's time to invest in British industry and put forward a plan for real jobs, that pay a decent wage.
"It's not rocket science, but such a level of common sense seems to be escaping ministers, who are busy concentrating on backbench Brexit squabbles, and not sorting out the economy.
"And when the Government does try to tackle industry issues, it fails to include any voice for workers, giving the impression that their views aren't legitimate despite working at the coal face in British industries."