Ago Outsourcing said the jobs boost was part of a five-year strategy to invest £40 million in the business.
The company’s sales division will create 90 roles from the end of this month, with a further 380 posts in customer service, financial services and social media set to follow early next year.
Denise Cassidy, contact centre operations manager at Ago, said: “This announcement could not have come at a better time for this sector, and I’m delighted that East Kilbride has been selected as the hosting location.
“The site is state-of-the-art, and the operation will, without doubt, be a very desirable opportunity for many people.”