The classic game show will be back as part of the Stand Up To Cancer fundraising event, which is on Channel 4 in October.
Reports suggest former Doctor Who David Tennant is tipped to host.
The problem-solving show - which saw contestants taking part in a series of challenges in order to win “time crystals” - ran from 1990 to 1995.
It drew up to six million viewers at the height of its success.
The programme was originally presented by Richard O’Brien, with Ed Tudor-Pole taking over for the final two series.
A spokesman for Channel 4 said: “Channel 4 is looking at a special Crystal Maze for Stand Up To Cancer.”