The pro-independence Yes Scotland group will attempt to capitalise on opposition to Conservative-led austerity measures with a weekend of campaigning.
About half a million leaflets will be distributed to try and show what policies Scotland has opposed but Westminster has pushed forward.
Yes Scotland said it is the “third key strand” of its campaign.
The group said a majority of Scottish MPs opposed the Chancellor’s austerity cuts, higher VAT rate, welfare cuts, bedroom tax and Royal Mail privatisation.
Chief executive Blair Jenkins, who will speak at a Social Liberal Forum tomorrow, said: “Westminster’s track record is what explains the way the No campaign are fighting this campaign. They are trying to defend the indefensible.”
A spokesman for Better Together, the campaign to keep Scotland in the UK, said: “The SNP wanted to break up the UK when Labour were winning elections and they want to break up the UK now the Conservatives are in government.
“The referendum is not a vote on the government we would like in the next five years, it is a vote on the future of our country for the next 300 years.”