Lung cancer patients get targeted new drug

Published on 03/12/2012 00:00

A “PERSONALISED” lung cancer pill to be launched today offers new hope to sufferers of a rare form of the disease.

The drug, crizotinib, targets a protein found in around five in 100 patients with the most common type of lung cancer.

Typically, these patients are much younger than average and do not appear to have a disease closely linked to smoking.

Marketed as Xalkori, the treatment was given an early licence by regulators after promising trial findings.

A Phase III study of 347 patients found that the drug more than doubled the time taken for treated tumours to start growing again or stop shrinking.

So-called “progression-free survival” was increased from a mid-point of three months for patients on chemotherapy to 7.7 months. Although survival time was not studied, researchers believe the drug has the potential to extend lives.

Crizotinib is the latest in a new generation of cancer drugs tailored to individuals with specific genetic make-ups.

It acts on a protein called ALK which blocks anti-cancer signalling pathways.

Patients who can benefit from crizotinib are identified by analysing biopsy tissue samples. They form a distinct subgroup among patients with non-small cell lung cancer, which accounts for 80 per cent to 85 per cent of lung cancer cases.

Dr Ekaterini Boleti, a member of the trial team from the Royal Free Hospital, London, said: “This is like a new entity within lung cancer. These patients tend to be younger than the average patient with lung cancer, and tend to be non-smokers or light smokers.

“It’s not a cure … but it’s a huge leap forward compared with what we had before.

“In the future, cancer treatment is going to be much more targeted and personalised.”