Conan Doyle manuscript to fetch £250,000

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AN original manuscript for one of Sir Arthur Conan Doyle's last Sherlock Holmes stories is expected to sell for more than £250,000 at auction.

The Edinburgh-born writer made more than 100 changes in black ink to his original hand-written manuscript for The Adventure of the Three Gables, which was published in The Strand magazine in October 1926.

The changes included crossing out words and whole phrases or sentences being replaced. A complete manuscript of a Sherlock Holmes story which had been so extensively altered is an item "of the utmost rarity", according to Marsha Malinowski of the auctioneer Sotheby's.

The item will appear as part of the New York sale on June 21. Edinburgh University is believed to be among the prospective buyers. Conan Doyle based his famous detective on Dr Joseph Bell, the surgeon and criminal psychologist who lectured at the university.