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Antibiotics crackdown in war on superbugs



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Published Date: 20 July 2008
MEDICINES for hospital patients are to be rationed under radical new plans to halt the spread of killer superbugs.
New guidance has been issued to doctors and nurses urging them to cut and delay doses of commonly prescribed antibiotics because of their role in the rise of hospital-acquired infections.

The initiative is an attempt by health officials to slash t
he use of antibiotics in hospitals by up to 25% each year, scrapping up to 83,000 routine prescriptions for conditions such as chest and gut infections.

Experts say the move will help the fight against the superbugs Clostridium difficile (C diff) and MRSA because although antibiotics kill some bugs, they cause others to spread.

Doctors and campaigners welcomed the plan, but critics warned individual patient care must not be compromised.

The guidance has been issued to health boards by the Scottish Antimicrobial Prescribing Group (SAPG), a panel of medicines experts, as part of the Scottish Government's drive against hospital-acquired infections.

The current culture of administering general antibiotics to many emergency admissions 'just in case' they respond to treatment will end. Instead, tests will be carried out to establish which, if any, antibiotics would be the most effective, delaying treatment by 24 hours.

Certain widely used antibiotics, cephalosporins and quinolones, believed to be particularly linked to the spread of C diff and MRSA, will be strictly rationed.

Antibiotics are implicated in the spread of superbugs because of they way in which bacteria respond to them. In the case of C diff, they kill 'good' bacteria in the gut that prevent C diff from growing and spreading. In the case of MRSA, the bacteria have grown resistant to certain types of antibiotic.

Professor Dilip Nathwani, chairman of the SAPG, said antibiotics "are being given for too long and the wrong ones are being given".

"Doctors and nurses need to think about whether patients need antibiotics and what the risks of antibiotics are."

Doctors would also be asked to keep duration of antibiotic courses to a minimum. "In most situations it can be three, five or seven days," Nathwani said.

"We are not being arrogant about it, we are going to measure and monitor this."

The move comes amid an alarming rise in cases of C diff, which causes diarrhoea and can be fatal. There were 1,861 cases in patients older than 65 in Scotland between January and March – a 16% increase on the previous three months.

In recent weeks an outbreak of C diff at the Vale of Leven Hospital in Alexandria, West Dunbartonshire, affected more than 50 patients, killing nine.

Official figures released last week showed that in 2006, 40 patients were killed by C diff in the area covered by NHS Lothian and a further 36 in Greater Glasgow and Clyde.

The C diff superbug has overtaken MRSA as the one most feared by patients. MRSA cases have dropped from 985 in 2005 to 881 last year.

GPs have already cut back on prescribing antibiotics for colds and flu.

Dr Charles Saunders, chairman of the British Medical Association's consultant committee and a public health doctor in Fife, said: "The risk benefits of antibiotics have changed over the years and now is the time to reassess how quickly you should use them.

"I think this will complicate things a bit for doctors, but it will improve patient care. It is likely they are going to have to do investigations and wait before prescribing.

"A lot of patients expect antibiotics and it can be difficult to explain to them why they are not getting them at that stage.

"But doctors aim to make patients better. In the long term this is an education for doctors and the public."

Derek Butler, chairman of the campaign group MRSA UK, said: "We would also like to see quicker tests that give results sooner so patients can be given the right antibiotics within a few hours, instead of waiting days. Obviously, other measures are also critical in tackling superbugs, including hand hygiene and cleanliness."

Families of patients affected by hospital superbugs have also welcomed the guidance.

Linda McCafferty, whose 82-year-old mother Nellie died after becoming infected with MRSA following a stay in Glasgow Royal Infirmary, said: "I support this move and I also believe patients should be swabbed for superbugs both on admission and on leaving hospitals."

However, Scottish Conservative health spokeswoman Mary Scanlon warned: "It is crucial that patients are monitored and that whatever happens is in the best interests of the individual patient."



The full article contains 760 words and appears in Scotland On Sunday newspaper.
Page 1 of 1

  • Last Updated: 19 July 2008 10:37 PM
  • Source: Scotland On Sunday
  • Location: Scotland
  • Related Topics: Hospital superbugs
 
1

subrosa,

20/07/2008 00:12:40
As a survivor of c.difficile I welcome this announcement. My troubles started with a hospital issuing a wide spread antibiotic after a small op. When I asked why I needed it I was told 'Anyone who has had invasive surgery gets these'.

Thankfully that misuse will now come to an end.
2

Guga II,

Rockall 20/07/2008 02:57:36
Limiting the use of antibiotics, and checking patients for infections is all well and good, but these measures are of limited value unless they start checking all hospital staff regularly for infections. Moreover, until they start enforcing hygiene amongst hospital staff, they are also wasting their time.

With regard to antibiotics use, there is often a disproportionate time between taking swabs and getting results. Some hospitals take as much as a week to obtain results. That is pathetic in this day and age.

Both nurses and doctors should be required to use hand washing, or alcohol gel, and new rubber gloves between patients. This does not happen in many cases, and doctors appear to be the worst offenders.

Nurses should not be allowed to wear their uniforms outside, or when coming from and going to the hospitals. Male doctors should be forced to get rid of ties, and no doctors should not be allowed to wear their street clothes in the hospitals; and that includes specialists.

It might also help if hospitals got rid of their excess "managerial" staff and employed more cleaners; and a strict regime of cleaning was enforced. Perhaps they should also start using Lysol again.
3

C.U. Jimmy,

20/07/2008 04:40:54
So we must take it that up until now there was no rationing of medicines for hospital patients? Unbelievable. If only this Government's way of collecting taxes was as casual as the way it spends them...
4

FTH22inarow,

20/07/2008 08:02:03
3 good grief!!!
5

FrankJB,

Old York 20/07/2008 08:26:03
#2 That is the way to go, definitely. If I can say a little of what happens in other industries which also rely on hygeine...

I am in sales in the food industry. As such I regulary vist my customer's factories and am forced to comply with their hygeine standards, which are streets ahead of anything in the NHS it would seem.

I went into a factory last week making packets of sliced meats for one of the supermarkets.

1. At the front door, I had to change my shoes to a pair that they provided.
2. Before being aloud entry I had to remove all things from my pockets, my watch and all jewlery apart from my wedding ring - and my jacket, mobile, pens, money etc.
3. On going in, I had to roll my shirt sleeves up to my elbow and wash with bactericidal soap and hot water.
4. I had to put on a clean / sterilised coat, and white clean wellington boots and then walk through a boot wash.
5. Then I had to wash my hands again
I went down another corridor where the workers seperate into "high risk" (already cooked meats)or low risk (raw meat - yes, they wash this much to work with raw meats!).
6. I went into the high care section, where I had to chane my wellies (again!), put on a steriliesed coat, sterilised overtrousers and sterilised plastic gloves. Then guess what, I had to wash my sterilised gloves (with them on) using bactericidal soap.
7. Then and only then was I let in...

Compare this to anything in our hospitals. With doctors relectant to remove their ties or nurses reluctant to take of their jewlery for example!

And yes, the food industry has just as many managers worrying about paperwork, procedures and comformances and not beig able to find time to check what is hapenig on the factry floor!

Hopefuly the medical sector could learn somthing here? Or probably they will just keep as they are!
6

Southsider once upon a time,

20/07/2008 09:37:13
Why the irresponsible lead to the article?
Surely this is not rationing but putting an end to over-prescription. The tenor of the opening sentences , and the headline on the front page, gives a negative view of a very sensible and necessary measure.
The over-cautionary use of antibiotics and other antiinfectives has come from demand from pataients who are not best placed to judge clinical need and from medics who have had to respond to these demands to avoid criticism.
7

brookit-bairn,

Madrid 20/07/2008 10:58:43
Dear Sirs,
This is all the fault of the drug-companies who do not wish people to use more effective alternatives which cannot be profitable marketed. Do a google on : phage. A little basic science will help
C.
8

subrosa,

20/07/2008 12:16:39
# 2

Agree totally with you. One aspect you have missed that is just as important is the lack of control of visitors to hospitals. People drift in and out without any hand washing or respect for hygiene. Something has to be done to bar visitors from wards unless they undertake hygiene procedures. Over the past year I've watched visitors drift into wards at any time of day without even glancing at the hand washing facilities.

#7

Thanks. Interesting. C.difficile only has two antibiotics which help. The first is a cheap one used widely. The second is expensive (vancomycin). I had to literally beg for that one but it worked efficiently and without any side effects.
9

peggy brooks,

chespeake 20/07/2008 14:45:33
GOD BLESS all those who've died w/ this terribull BUG now I wonder, I should I seek legal counsil for my recent husband's death;altho he had other illnesses,DOCTOR's were baffled how & why my husband was STILL aLIVE;after being told,he wouldn't have long to live,....2years later & minus a removeal of one defibulater/pacemaker;AND!!!! 25% increase in his heart stength(had triple bypass 15% heart stenght)he also had this SUPERBUG; 4 over 8 wk.'s & inspite of it all he lived(WHILE in the hospital) later ;only to die from ahost of other promblems;BUT!COULD this BUG played a part in his death??? I'LL FIND OUT!!!! U BET CHA!!!! BEST WISHES,pb; never give up hope!;)
10

caedmon,

missouri 20/07/2008 15:17:36
RE #6,7:
Having only two narrow-spectrum ABs in the C.diff arsenal is no safe situation--add to this the fact that a metranidazole-resistant (the cheaper of the two ABs) strain of the bug has been identified recently, and you have the conditions for a very dark scenario.

The fact is that this is a wildly-successful organism: first identified in the 1950s, and with a VERY hardy dormant spore-stage, it seems to have mutated fairly quickly into several different strains of varying virulence...no doubt the regular wiping-out of competing bacteria (eg e.coli) in the intestinal playing field is a direct cause here.

There are various alternate therapies...one of which, non-drug-using and when effective, ~permanent (no recurrent infections)...
--wait for it...
--brace yourselves...
Is to obtain C.diff-free fecal samples(from a non-infected person)--ie full of "friendly" intestinal microflora, prepare in a slurry...and introduce to the affected person's gut via a direct delivery (either enema-wise or...!!naso-gastric tubing)...

No irresponsible administration of broad-spectrum ABs is far preferable!!!
11

JennyA,

Scotland 20/07/2008 16:44:37
Yes - I caught C.difficile in an NHS Hospital after getting two broad spectrum antibiotics, Metronidazole and Cefuroxime,(a Cephalosporin, one of the antibiotics implicated in C.difficile development). With bowel operations antibiotics are ALWAYS administered beforehand to prevent infections (prophylaxis);but I was also given a 4 day course of these same antibiotics. I'm not sure why. I have been told that I did NOT have an infection. I was in a ward bay with other patients who had diarrhoea. I had NO chance of avoiding this devastating infection. I am glad that Dr Nathwani and his team are at last going to tighten up on antibiotic prescribing in hospitals. Previously, they were only bothered about antibiotic resistance which produced those horrors MRSA and VRE. It might also be helpful to take extra precautions with patients who HAVE to receive antibiotics for diagnosed infections. I shared 'obs' machines with those other patients and was put far too close to another patient. Only a flimsy curtain separated us. Care also needs to be taken with drinks containers etc left on tables and lockers. Bedmaking can disturb C.difficile spores which can settle out on to surfaces and anthing else left exposed.
12

subrosa,

20/07/2008 22:40:05
# 10RE #6,7:
'Having only two narrow-spectrum ABs in the C.diff arsenal is no safe situation--add to this the fact that a metranidazole-resistant (the cheaper of the two ABs) strain of the bug has been identified recently, and you have the conditions for a very dark scenario.'

I'm a survivor of c.difficile. As per your post I would have no problem is having the 'slurry' of anyone with healthy flora being pumped into me. Far better than the life or death scenario I went through believe me.

Luckily I'm well under 65 and reasonably healthy. It is with this in mind why I can fully understand that someone with other health problems succumbs to this bug. It has taken me 18 months to more or less recover, but I am left with lifelong health problems now. Mind you I'm alive and able to lead a reasonable life - no thanks to my GP I must say, who insisted for two weeks, that I had food poisoning.

13

subrosa,

20/07/2008 22:42:43
# 11

My sympathy Jenny. Hope you're back to as normal as possible. My hospital was dirty, in fact filthy really and visitors were allowed in anytime without any hand hygiene. I doubt things have improved and I dread having to go into hospital ever again.
14

linda mccafferty,

Glasgow 21/07/2008 00:14:03
I have had a mother infected with mrsa which contributed her death , a sister infected with mrsa who had to get her wound that had all burst opened packed for 7 month's & now just in feb, this year my partner who was infected by not only mrsa but c-diff also ..............how many more of my family members are to suffer this !!!!!!


Post #5 it's common knowledge that out abbattoir's are hygienically cleaner than our hospitals .
15

Alanmar,

21/07/2008 19:41:46
`
Sorry #3,#4 the reason why rations are being imposed is surely because anyone with anything between the ears knows that Antibiotics along with Antibacterials have been overprescribed and abused for several decades now.

The Food Standards Agency (I presume, blog #5 you refer to hygiene standards of FSA) and the NHS have different agendas, but the bottom line has always been cyclopean interests and short term cash returns, Capitalism style. Long-term health and the big picture have in both cases been largely ignored. (Meanwhile the Pharmas have done very nicely, thank you.)

We are just STARTING to pick up the pieces. We need a more caring capitalism because the many "experts" who left us this legacy, will be regretting it for years to come. It may too be the same with global crises of other sorts: the crunch had to come sometime and that time is now.
`
16

Pink Sombrero,

27/07/2008 00:27:17
1. Simplistic. You would, I am sure, be ( i hope) complaining if you had acquired a common infection post surgery.

Is not such an easy question as prescribing less anti-biotics post surgery.

 

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